Experts in formulation and manufacturing
iDPC Manufacturability
APT’s technology offers a novel, low shear, one-step micro/nano particle layering operation that processes materials without the use of solvents, heat, propellers, baffles as well as avoiding any physical or chemical change.
APT offers an extensive suite of formulation and process development opportunities including optimisation of lead candidates, pre-clinical development and a range of characterisation and analytical capabilities
Key Advantages of iDPC
Existing particle coating technologies often comprise of multi-step liquid based processes and operate at temperatures that are not suitable for heat and moisture sensitive materials. There is an inherent limitation in the availability of techniques for particle surface modification that do not chemically or physically modify the innate properties of the particle itself.
iDPC technology to date has been applied to applications in respiratory, oral drug delivery and biologicals.
iDPC presents many advantages over traditional blending technologies, e.g. low and high shear mixes of all types, and the current suite of advanced manufacturing technologies which require the generation of controllable and precise particles to achieve good dispersion and API delivery e.g. spray drying.
Manufacturability
- Able to process small molecules and biologics with wide range of physical properties across a wide concentration range from 0.1 - 90% w/w API at ambient temperatures
- Bench scale formulation directly scalable to pilot scale process (2 kg) with semi-continuous manufacturing in advanced development (10kg/h)
- Low shear process without the need for resting and quarantining processed powder formulations
- iDPC is driven by a low energy mechanism, no highly energetic particle/particle collisions and no particle attrition, consequently minimal physical alteration of the constituent materials occurs
- The mechanism minimises solid/solid interactions - no charge separation (no triboelectrification), no discharge and no heat generation
Broad Applicability
- In-process controls achieved by a Quality by Design approach that optimises 3 simple critical process parameters
- Immediate downstream processing after preparation - predictable performance smoothes manufacture and supply chains
- Micro onto millimetre, micro onto micrometre and nano onto micrometre particle layering
- Can process small molecule APIs for respiratory or oral solid dose formulations as well as biologics (including hydrophilic, hydrophobic, crystalline or amorphous, poorly flowing, heat or moisture sensitive APIs)
Sustainability
- Cost effective SMART strategies
- Green manufacturing technology
- Accelerate progress on carbon reduction