Aston Particle Technologies
iDPC Mechanism
iDPC drives the adsorption/adherence of fine “guest” particles onto the surface of coarse “carrier” without pre-conditioning particles leading to formulations with enhanced functionality, stability and predictable performance.
Aston Particle Technologies, pioneers in providing innovative formulation solutions for small molecule and biological APIs through patented isothermal dry particle coating (iDPC) technology.
Introduction
iDPC Mechanism – 3 Steps
iDPC process consists of 3 simultaneous stages, an initial de-agglomeration, followed by particle dispersion and culminating in particle adsorption onto the larger carrier particles.
- De-agglomeration: iDPC occurs in a chamber at rotating at high speed resulting in the formation of a thin layer at the chamber walls at which the cohesive particles are de-agglomerated.
- Particle Dispersion: Introduction of a gas blade disrupts the thin layer, forming small fluidised pockets which drive the mixing of the particles and disperses the fine particles amongst the coarse particles delivering excellent content uniformity.
- Adsorption: The dispersed fine particles adsorb onto the surface of the coarse particles in discrete fractional, ‘monolayer’ or multilayer coatings as a function of the relative concentration.
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