Respiratory Formulations
iDPC delivers dry powder inhaler formulations across an unprecedented concentration range, formulating both traditional and high dose DPI without subjecting the material to heat, moisture or triboelectrification.
iDPC has the capability to smooth supply chains through just in time manufacture (no requirement for blend resting/quarantining) with stable DPI performance over formulation lifetime
High Dose DPI Formulations
- iDPC extends the capability of traditional carrier-based DPI formulations to deliver previously unachievable inhaled doses
- Processable formulations can incorporate up to 90% w/w API and can utilise jet-milled API
- No requirement to alter the physical/chemical state e.g for spray drying or porous particles
- iDPC formulations utilise GRAS excipients
- Controlled dose, controlled fine particle fraction (FPF) and controlled stability profile
Low to high dose SEM Images of 0.7 to 25%w/w concentration.
Traditional and Fixed Dose Combination
- iDPC extends the capability of traditional carrier-based DPI formulations to tailor the dosing performance of FDC products
- Formulation of Double and Triple Combination products by Design
- Designed experiments to define optimum processing conditions at benchtop scale (typically <1 -5g blends) without the need for pre-conditioning of materials or requirements for additives, e.g. force control agents
- Optimum blends scaled at kilogram batch size from defined Control Space identified at low scale manufacturing
- Reproducible controlled manufacture of multiple batches at higher scale
